Showing posts with label estrogen. Show all posts
Showing posts with label estrogen. Show all posts
Tuesday, January 24, 2017
Great News! PMDD Tied to Sex-Hormone Reactive Genes
Today's guest post welcomes author Eryn Speers' unvarnished reaction to the news that National Institutes of Health (NIH) researchers have
discovered molecular mechanisms that may underlie a woman’s susceptibility to
disabling irritability, sadness, and anxiety in the days leading up to her
menstrual period. I couldn't have said it better myself, which is why I asked permission to reprint Eryn's original Facebook post here.
The bottom line is this NIH discovery is good news for us all. Please be sure to watch the five minute video (link provided) at the end.
I have been through the gambit, had my moments of doubt, and
a few good months where I thought I was "free" of PMDD. Chalking it
up to stress, or difficult times, only to have it return with a vengeance. In
my frustration I began my research again, shaking my head every time I ended up
down the same road: eat clean, eliminate sugar and caffeine, get your hormone
levels checked, get acupuncture, see a naturopath, try anti-depressants and
Cognitive Behavior Theory. The list goes on and on, as we know. What I, myself, have come to realize,
is that all this conflicting information just makes it all worse. That's why I
am taking this new research as a cue to stop blaming myself, and to stop
listening to all the noise and babble about what the "correct"
treatment of PMDD is. While it's a good idea for anyone to reduce sugar intake,
exercise regularly, and investigate possible food sensitivities - these things
will make anyone feel better in general, but to continue to go in circles just
adds stress to what is already a stressful situation.
I hope this new research helps others to do the same. Yes,
it means we still suffer until they find a way to use the info to come up with
a therapy that targets the actual cause of the problem, as opposed to the
symptoms. However, at least those of us who are desperate and tired of trying
everything to no avail, can try to find some hope in knowing that they are
really working on it.
This is a disorder on a cellular level, and I am ready to
accept whatever treatments they come up with in order to get my life back. My
hope is that those of you who are very anti-pharma will try to trust, for a
while, and give yourself a break from feeling that the only one who can correct
the problem is you.
This puts so much undo pressure on us, and also nurtures an
environment of pessimism and fear. We deserve to feel better! This problem is
not caused by us. This is not a matter of poor diet or lifestyle choices, or a
hormonal imbalance. All we can do right now is cope as best we can, and we're
all doing that.
We're here to support one another, and I feel that we should
all encourage one another to stay open to the possibilities as the research
advances. Please, I implore you to keep trying new therapies until you are
finally free of this awful disease. If you want to take anti-depressants in the
meantime because they help, great! If you want to take birth control, or stay
100% natural in your efforts to get through and lessen the severity of your
symptoms - also great!
However, please don't let the way this disease makes you
feel hopeless and useless allow others to tell you exactly how to approach your
own health. Don't let the fear and skepticism of others stop you from trying a
drug that has been specifically developed to treat this issue in the future.
They ARE working on it.
Have faith! ~ES
Friday, July 4, 2014
Chemical Sensitivities and PMDD
Over the years I've become increasingly more
sensitive to chemicals, fragrances, and any kind of scented products, be they
cat litter, candles, or cosmetics. If a
product has a petroleum base and a name that is clearly made up--such as Ocean
Breeze or Home Made Apple Pie--I need to stay as far away from it as possible. I first discovered this over twenty years ago
when a woman walked into the office where I worked and offered to sell me knock-off
versions of expensive perfumes and proceeded to spritz them all over the
place. She left without a sale as I instantly
developed a massive headache that lasted the rest of the afternoon.
My list of substances to avoid grew from there. Wood smoke, treated lumber, paraffin candles,
any kind of scented candles or room deodorizers, home cleaning products, paints
and stains, body lotions, soaps, shampoos, deodorants, and eventually, even the
real brands of premium perfume. I now can't go to the mall, pet store,
electronics store, furniture store, home improvement store or beauty shop
without taking a Benadryl. I need to
stay out of the cleaning products, pet supplies, paint, tire, shoe, furniture, and
home accents aisles in discount and department stores.
As for seasonal items like the Christmas aisle with
its scented pine cones and stuff? Forget
it. Neither can I visit used book stores
anymore, without succumbing to the smell of mold and must.
Recently, we uncovered water damage to a house we
bought three months ago and have yet to move into. My husband wants to strip the wallpaper, re-paint
and re-carpet the house, then air it out before I move in. The last house I moved into eight years ago
was new. I moved in early February and by
mid-April was so sick I collapsed. It
took another two months to recover, once I discovered problem: off gasses from the building materials such
as my carpet, vinyl, and laminate flooring (didn't help that this was winter
and my floors are heated), paint, kitchen counters and cabinetry. I thought I was just getting older. I did a lot of the move myself, moving one
mile down the road from my previous house, one carload at a time. Eventually I was sleeping all the time, but
unable to get any rest. My mind became
so foggy I couldn't get much of anything right.
I recall my boss asking, "Liana, what is wrong with you?"
A recovering perfectionist, I rarely made mistakes,
and suddenly I was making them all the time.
I was sitting at my desk, staring dumbly at no doubt my latest mistake
on the computer screen, and I remember telling her, speaking very slowly
because it was hard to form the words in my mind, "I...don't...know...all
I want...to do...is sleep." I called
the builder to ask if there could be a reason I was so tired and fuzzy-minded
all the time, and he suggested it was because I had no curtains and was getting
too much light in the house. Turned out all
I needed to do was open the windows. My
super energy efficient house was trapping all these off-gasses inside with me,
and I was breathing them over and over and over again. Within a week the house was cleared out, and
I was on the road to recovery.
But yesterday I took a trip down memory lane. Due to the water damage in our new home, my
husband and I had to go door shopping.
We also had an appointment to speak with a kitchen designer for a
remodeling project. To price doors, we
stopped at another builders supply store on the way. The salesman was wearing such strong cologne
I had to stand at least 15 feet away from him while he spoke with my
husband. As we left, I told my husband I
suddenly had the urge to eat anything and everything in sight, which is
something that happens when I get hormonal prior to my period. The thing was, we had just eaten breakfast
before leaving for the builders supply store, so I knew I wasn't hungry.
It was a combination of the man's cologne and the
smell of new building materials making me feel like I was starving.
We got to the second builders supply store, where we
had the appointment. Halfway through, my
husband said, "Your face and neck are turning bright red." The store was filled with carpet and flooring
samples, tiles, and kitchen and bathroom cabinetry. My husband left to get me a diet soda, which
for some reason I have yet to discern, always cuts my reaction to various substances.
When he returned, I took a Benadryl, which also helped to ease my symptoms
somewhat. But by the time we had been in
the store an hour and a half, even with taking the Benadryl and drinking the
diet soda--it has to be diet for this to work for me--my fingers started
swelling and tingling. By the time we
left, my wrists were tingling. It
usually moves up my arm and into my shoulders if I don't take a Benadryl and/or
remove myself from the situation. But
once it starts tingling, I know it will get painful very soon, as my insides will
swell up and press on the meridian nerves in my arms. I had this constantly when I was pregnant, so
much so that nightly I would sit in my rocking chair with my big belly and cry
from the sheer pain of it.
(Pop quiz. What happens when you are pregnant? You are an estrogen factory.)
So we wrapped up that appointment and headed for the
paint store, to get sample cards of the color we had chosen for the kitchen. I was not in the store three minutes before I
noticed I was firmly massaging my arms, something I do when my body gets
stressed from chemical exposure and starts to hurt. I didn't smell a thing, but then I don't need
to smell anything before my body reacts.
I discovered this one night when leading a faith sharing group at a
friend's house. She knew I couldn't be
around burning candles, but the moment I walked into her house, the words
"Something's wrong" blurted out of my mouth. No one heard me, and I took my regular seat
on the floor in front of the couch, as due to back problems I cannot sit on
soft furniture. I saw no candles in the room, but as the meeting progressed, my
head started to spin and pound and first my hands, then arms, then whole body
began to ache until the pain felt like it was deep in my bones and all I wanted
to do was curl up in a fetal position and cry.
If I hadn't been leading the meeting, I would have
left. Finally, I asked my hostess,
"Are you sure you didn't burn any candles in here before we came tonight?"
and she swore she hadn't. I said,
"Well something's wrong with me and I can't figure it out." Did you do any special cleaning for the
meeting? "No," she said, "all
I did was spray the couch with Febreeze."
The same couch I had been sitting on the floor leaning
up against all night.
My intuition knew something was wrong the moment I
entered the room. My mouth even blurted
it out. I didn't smell a thing, but my
body reacted instantly and painfully. To
this day I cannot be anywhere near Febreeze.
I wince just watching the commercials, people spraying it all over their
homes, laundry, and cars.
But back to our shopping trip. After the kitchen design appointment, my
husband stopped at two more building materials stores to check prices. I did not go inside. I was feeling a bit battered by then. After he came out of the first store, instead
of turning the car around and leaving, he made a circle by driving thorough the
warehouse, where contractors pick up loads of lumber. I groaned inside as the fan system in our air
conditioned car pulled in the scent of all that treated lumber. After we visited the second store, and then
the paint store, I announced, "We're going to get something to eat. Right now." We went to a sub shop, and I wolfed that baby
down so fast you would think I hadn't eaten in three days. Thank God it wasn't our first date or my
husband would have wondered about this woman who eats like a Doberman.
As soon as I finished my sub, my husband
says..."There she is. My wife is
back again." During the appointment
and shopping stops, I had become listless and withdrawn, my energy sapped. I could barely focus on the choices they
wanted me to make. I just wanted to get
out of there. I had chosen that store
because the woman and I had worked together before twice. We hadn't seen each other in nine years though,
and since then, I'd entered perimenopause.
She was tall and thin and stylishly dressed, while I was feeling fat and
puffy, dim-witted and inadequate. Afterward,
I determined (in my building-materials-chemical buzzed mind) that I was a
failure in life and wouldn't return to that store ever again because the
differences between us threw into stark relief her success and my failures.
Hello? I'm
now descending into a full-blown case of PMDD.
My insecurities are rising, and my mind is starting to go
irrational. By now every word my husband
speaks is starting to irritate me, so I withdraw even further into myself and
look out the window and keep my mouth shut, because I know if I open it, I will
explode with anger and resentment and he will get this shell shocked look on
his face.
We get home, and all I want to do is go to my
computer, where behind the veil of the internet, I can answer questions about
PMDD and help people to understand the disorder and feel like I am making a
difference in someone's life. I need
this feeling in this moment to feel any sense of self-worth.
This is how badly these building materials chemicals
have distorted my thinking processes.
Instead, I ask my husband if he wants to go for a
walk. Maybe the fresh air will clear my
head and make me feel better, because by now I ache all over and just want to
go to bed and curl up under the covers and cry.
Instead, we pass a few lawns freshly treated with
pesticide, and I come home feeling worse than ever.
The evening is a loss. The only option for me is to take another
Benadryl and go to bed.
Where it turns out I cannot sleep, my mind is so
agitated and upset. I can't stop
thinking about how insecure and inadequate I felt during my kitchen design
appointment. How overwhelmed I was by
the whole process. That is not me. I have
designed and built two houses and remodeled two others. I can do this stuff in my sleep. But inundated by the scent of building
materials, I lost my self-confidence and sense of self-worth, and in essence
brought on an episode of PMDD.
If I hadn't turned red and my husband hadn't noticed
it, I would never have known what happened.
If this had happened years ago (and maybe it did,
I've simply forgotten), I would never have known what happened. Instead, I would have spent a few hours
looking at building materials, chosen the cabinets, tile, flooring and paint
for what promises to be a beautiful kitchen, and come home feeling overwhelmed,
worthless, insecure, sad, angry, frustrated, combative, weepy, and ravenous,
and never understood why. That, in turn
would have made me wonder if I was crazy.
Here I am, getting everything I want, and yet all I want to do is snap
my husband's head off. I want to lash
out at him so badly I hurt from containing all my rage inside.
Or so I think.
In reality, my body is being chemically disrupted by what are called
xenoestrogens, and they are playing havoc with my hormones, and that is f*****g
with my brain.
So the next time you're out shopping and come home
feeling any of the above, or visit a friend's house who uses petroleum-based
cleaning products, candles and/or air fresheners and come home feeling weird
and moody--know that it is not you. It
is the chemicals in the air around you messing with your mood and mind. They may also be making you feel physically miserable,
which brings on that endless loop of negative thoughts we're all so familiar
with, which in turn makes us feel sad and/or angry.
Look around you.
Look in your home. Do you use
these sorts of petroleum-based products?
Are you unknowingly making yourself sick? Some women report that they feel like they
are in the PMDD zone all of the time.
Sometimes this is due to perimenopause, but it could also be due to what
you touch and breathe in all day. Do
you work in an auto parts store? A
furniture store where most of the items are made of particleboard? At the
mall? A lumber yard? A kitchen and bath store? An electronics store? Do you clean houses for a living? Are you a flight attendant? Did you just move your office into a new
building or remodel your home? Are you a
cashier and handle thermal paper receipts all day?
There are any number of options for how and where
you can be exposed to these xenoestrogens that wreak havoc on your
hormones. Awareness is the key.
But most of all, when you start acting all funky and
not like yourself at all...look around you for a possible reason. Did you just buy tires and sit in the waiting
room while they were put on? THINK about
this. Think about where you go and what you do.
I bet that suddenly a few things will start to make
a lot more sense.
Sunday, March 9, 2014
Scientific Awareness of PMDD is not the Problem
Almost daily I hear someone mention how we need to raise
awareness of PMDD, so that more studies of this debilitating disorder will be
done, and someone can finally unlock the secret of what causes PMDD and how to successfully
treat it.
So one day last August, a week before my most recent brain surgery, I was apparently looking for some challenging reading material when I
got out of the hospital, (thinking positive, I imagine) so I spent an hour and
a half clicking on links and printing out various scientific abstracts and studies
I could find on PMDD.
In just that small segment of time, I found nearly 50 studies
on PMDD, which broke down as follows:
2013 - 19
2009-2012 - 18
2006 - 2008 - I
already have most of these in my files, so did not print them out again
2001-2005 - 10
I am sure there have been countless more studies done in the
past 14 years, but this was a random sampling of those I might not already have
read, and I also chose not to print out many that were over 7 years old, as so
much information about PMDD has changed since 2007.
Of the 2001-2005 studies, I printed only those that might be
of use in my research. A list of titles
appears below. And yes, I do intend to
read each study listed, and share with you in plain language anything that
seems relevant. But first I want to point
out that in the scientific community, the problem is not awareness. Scientists are well aware of PMDD and for
what looks like mixed reasons. An analysis of what those reasons might be will
be the subject of a future post.
For now I just want to repeat that awareness on a scientific level is not the problem. Awareness in the medical community—short of misleading
advertisements by drug companies—and awareness in our friends and families is. Hopefully blogs like mine will help to
rectify that situation for you and your loved ones.
In the meantime, here is a list of the studies on PMDD I
uncovered in less than two hours of searching.
If you think the list is dry reading, imagine reading the studies
themselves :). But like I said, it keeps
my brain sharp. Not to mention I'm a total research geek and love it.
If you wish to read any of these studies yourself, you can
Google the name provided. I typed the
titles exactly. Just retype it yourself, or cut and paste the
title into your browser. These can all
be found on the PubMed.gov site, which is part of the U.S. National Library of Medicine, and the
National Institutes of Health. Many of
them are abstracts, but you *can* find the full studies if you look hard
enough. Update: the first comment below tells you exactly how you can get copies of the full studies.
Enjoy!
2013
Comorbid bipolar disorder and PMDD: real patients,
unanswered questions
Elevated gray matter volume of the emotional cerebellum in
women with PMDD
Allopregnanolone serum concentrations and diurnal cortisol
secretion in women with PMDD
Examination of premenstrual symptoms as a risk factor for
depression in postpartum women
Luteal serum BDNF and HSP70 levels in women with PMDD
PMS and PMDD among Jordanian women
Circulating insulin and leptin in women with and without
PMDD in the menstrual cycle
Abnormalities of dorsolateral prefrontal function in women
with PMDD; a multimodal neuroimaging study
Lamotrigine augmentation in PMDD : a case report
Depressive mood and frontal alpha asymmetry during the
luteal phase in PMDD
PMDD and severe premenstrual syndrome in adolescents
Selective serotonin reuptake inhibitors for PMS
Premenstrual disorders and rumination
Anger in women with PMDD: Its relations with PMDD and
sociodemographic and clinical variables
Non contraceptive benefits of oral hormonal contraceptives
Premenstrual symptoms and posttraumatic stress disorder in
Japanese high school students 9 months
after the great East-Japan earthquake
Personal history of major depression may put women at risk
for premenstrual dysphoric symptomatology
A review of treatment and management modalities for PMDD
Biopsychosocial aspects of premenstrual syndrome and
premenstrual dysphoric disorder
2012
Pilot investigation of the circadian plasma melatonin rhythm
across the menstrual cycle in a small group of women with PMDD
Bipolar disorder and PMS or PMDD comorbidity: a systemic
review
Survey of premenstrual symptom severity and impairment in
Korean adolescents; PMDD subthreshold PMDD and PMS
Intercountry assessment of the impact of severe PMDD on work
and daily activities
2011
Work stress, PMS and PMDD are there any associations?
Lifetime discrimination associated with greater likelihood
of PMDD
Posttraumatic stress disorder and trauma characteristics of
PMDD
Reduced Phase-Advance of Plasma Melatonin after bright
morning lithe in the luteal, but not follicular menstrual cycle phase in PMDD:
An extended study
Exposure to American culture is associated with PMDD among
ethnic minority women
Health advantage for black women: patterns in PMDD
2010
Histories of major depression and PMDD: evidence for
phenotypic differences
Neuroticism related personality traits are related to
symptom severity in patients with PMDD and to the serotonin transporter
gene-linked polymorphism 5HTTPLPR
Predicting response to leuprolide of women with PMDD by
daily mood rating dynamics
Estrogen receptor alpha (ESR-1) association with
psychological traits in women with PMDD and controls
Increased sensitivity to light-induced melatonin suppression
in PMDD
Prefrontal brain asymmetry and PMDD symptomatology
Explorative evaluation of the impact of severe PMDD on work absenteeism
and productivity
2009
Safety, efficacy, actions and patient acceptability of (Yaz)
contraceptive pills in the treatment of PMDD
2005
Lack of beneficial effects of clonidine in the treatment of
PMDD: results of a double blind, randomized study
Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women wit PMDD
Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women wit PMDD
2004
Historic sexual abuse and current thyroid axis profiles in
women with PMDD
2003
The prevalence, impairment, impact and burden of PMDD
Biological correlates of abuse in women with PMDD and
healthy controls
2002
Prevalence, incidence and stability of PMDD in the community
Prevalence and predictors of PMDD in older premenopausal
women. The Harvard Study of Moods and Cycles
2001
Characteristics of women with PMDD who did or did not report
a history of depression: a preliminary report from the Harvard Study of Moods
and Cycles
Allopregnanolone levels and reactivity to mental stress in
PMDD
Monday, January 27, 2014
Is it PMDD or Not?
This week I want to revisit a past post that gives several reasons (but not all!) why PMDD is so often misdiagnosed. It was originally called Confusion City.
I'm on my way back into the hospital for a follow up cerebral angiogram so prayers and positive thoughts welcome... Hope to be back here with a brand new post soon!
I'm on my way back into the hospital for a follow up cerebral angiogram so prayers and positive thoughts welcome... Hope to be back here with a brand new post soon!
Labels:
aldesterone,
blood serum testing,
cortisol,
DHEA,
estrogen,
hormonal balance,
hormones,
insulin,
melatonin,
PMDD,
PMS,
testosterone,
thyroid
Wednesday, October 13, 2010
Confusion City
This post was completely updated September 23, 2015
One of the main problems I find in researching PMDD is that every woman’s hormones fluctuate daily in concert with her menstrual cycle, so it’s hard to separate what’s caused by normal female hormonal fluctuations and what’s caused by PMS or PMDD. To be clear: PMS and PMDD are not the same. PMDD is *not* PMS on steroids, although it can feel like it when you’re having an episode.
There is a definite brain component to PMDD that is not present in PMS. PMS mostly deals with physical symptoms (aches, pains, tenderness, cramps, bloating, etc.), with some minor mood fluctuations…a little irritability, a lack of energy or motivation, some weepiness, maybe more anxiety than usual.
PMDD ratchets these symptoms up a few hundred notches, to the point that these mood disturbances affect your ability to function and maintain stable relationships.
A lot of books and websites discuss the more mild symptoms of PMS, and then simply transfer the same thoughts and theories to PMDD. A lot of these sources even call PMDD a more severe version of PMS. This is not true. They are two separate conditions that unfortunately have enough in common to confuse everybody. But in the end, they take two different paths.
One of the main problems I find in researching PMDD is that every woman’s hormones fluctuate daily in concert with her menstrual cycle, so it’s hard to separate what’s caused by normal female hormonal fluctuations and what’s caused by PMS or PMDD. To be clear: PMS and PMDD are not the same. PMDD is *not* PMS on steroids, although it can feel like it when you’re having an episode.
There is a definite brain component to PMDD that is not present in PMS. PMS mostly deals with physical symptoms (aches, pains, tenderness, cramps, bloating, etc.), with some minor mood fluctuations…a little irritability, a lack of energy or motivation, some weepiness, maybe more anxiety than usual.
PMDD ratchets these symptoms up a few hundred notches, to the point that these mood disturbances affect your ability to function and maintain stable relationships.
A lot of books and websites discuss the more mild symptoms of PMS, and then simply transfer the same thoughts and theories to PMDD. A lot of these sources even call PMDD a more severe version of PMS. This is not true. They are two separate conditions that unfortunately have enough in common to confuse everybody. But in the end, they take two different paths.
However, since they are often treated as similar, even
interchangeable, by many media, for years I thought I had PMS, and couldn’t
figure out why—if more than 80% of all women experience some form of PMS—why
couldn’t I cope like everyone else did?
Because it wasn’t the
same thing, and I didn’t know that.
So, while PMS affects (mostly) your body and (mildly) your mind on more or less a regular cycle, with more or less the same cluster of mind/body symptoms each month (specific to you as an individual), PMDD affects your brain’s ability to regulate itself, and therefore affects just about every other hormone in your body, too.
This is why you often feel as if something or someone else has taken over your body. You think one thing, and something totally different comes out of your mouth. You think you’re eating right, getting enough sleep and exercise, and suddenly one day you have no energy and your body simply won’t cooperate. There’s a missed connection there, and while it’s not “all in your head,” as many friends, relatives, co-workers, and even medical personnel would have you believe, it is happening in your brain.
So what are some of these hormones, and what do they do?
Here (in alphabetic order) are the ones most likely to affect your levels of PMDD.
Aldosterone – Never heard of it? Doesn’t matter. It still contributes to excess water weight gain when your progesterone levels are high, like in the second half of your menstrual cycle, when you feel all fat and bloated. Now you know (in part) why you get that way, and why (short of diuretics) there’s really nothing you can do about it but avoid salt, celebrate the fact that you’re a woman, and know that this, too, shall pass…
Androgens (DHEA and others) – When levels of these are too high they enhance your sex drive and aggressive tendencies, produce unwanted facial hair and apple vs. pear-shaped bodies in women, stimulate your appetite and contribute to waistline weight gain.
Cortisol – This affects your metabolism and tells your body to store more (more! more!) body fat, and is produced in even higher amounts under stress. (Remember, a woman with PMDD is more sensitive to stress to start with, so don’t be surprised if your levels are off the charts.)
Think about this: Our bodies have not changed much biologically since prehistoric times, and so are designed to respond to stress in a certain way that back then was perfectly normal and balanced. But stress back then might be due to a natural disaster, imminent death or starvation, attack by a wild animal, or, in later times, attack from a warring tribe.
Now our stress comes from sources like electronic devices, over-commitment, dashed hopes and unmet expectations, financial strain, unsafe drivers, emotional upsets, and major life changes like birth, death, marriage, divorce, surgery, change in employment or living location, to name just a few.
But our bodies still react in the same way they did in prehistoric times to these threats and upsets—as if we were literally under physical attack.
So up goes your cortisol, which, among other things, suppresses your normal immune functions, leaving you susceptible to every cold and flu that comes your way. In time your body can get so run down that you develop something serious, even terminal.
The Estrogens – Estradiol, Estrone, and Estriol These three wonder hormones are involved in over 400 crucial functions throughout your body and brain, including your metabolism, moods, body heat regulation, insulin sensitivity, pain levels (think muscle and joint pain, and headaches), and carbohydrate tolerance. Both too much and too little estrogen are bad for you, in ways too numerous to go into here. But know this—you have estrogen receptors in your brain, bladder, bones, muscles, blood vessels, skin, breasts, uterus, eyes, heart, and colon. It’s not just about sex anymore. With all those receptors, you can easily take in too much estrogen—or, more appropriately, too much of the WRONG kind of estrogen (aka xenoestrogens).
Insulin – Lowers your blood sugar, stimulates fat storage.
Melatonin – Regulates your sleep cycles and body rhythms, promotes fat storage for hibernation (remember those cave dwellers) and increases your appetite for carbs. Melatonin also plays a role in Seasonal Affective Disorder (SAD) syndromes that affect your energy levels, weight gain, daytime sleepiness, and depressed moods.
Norepinephrine and Epinephrine – aka your Adrenaline Hormones. These govern your “fight or flight” responses. They increase your heart rate, lift your mood (or in excess cause anxiety), increase alertness, and dilate your arteries to provide more oxygen, glucose, and nutrients to your key organs in times of distress.
Remember what I said about how our bodies were initially designed to respond to threats and the differences between threats then and threats now? Some of us are living in a nearly constant state of fight or flight simply due to the lifestyles we live. But on top of that, when a woman enters her PMDD zone, her fight or flight switch comes on, but because of some missed connection in the brain—it does not shut off.
So, while PMS affects (mostly) your body and (mildly) your mind on more or less a regular cycle, with more or less the same cluster of mind/body symptoms each month (specific to you as an individual), PMDD affects your brain’s ability to regulate itself, and therefore affects just about every other hormone in your body, too.
This is why you often feel as if something or someone else has taken over your body. You think one thing, and something totally different comes out of your mouth. You think you’re eating right, getting enough sleep and exercise, and suddenly one day you have no energy and your body simply won’t cooperate. There’s a missed connection there, and while it’s not “all in your head,” as many friends, relatives, co-workers, and even medical personnel would have you believe, it is happening in your brain.
So what are some of these hormones, and what do they do?
Here (in alphabetic order) are the ones most likely to affect your levels of PMDD.
Aldosterone – Never heard of it? Doesn’t matter. It still contributes to excess water weight gain when your progesterone levels are high, like in the second half of your menstrual cycle, when you feel all fat and bloated. Now you know (in part) why you get that way, and why (short of diuretics) there’s really nothing you can do about it but avoid salt, celebrate the fact that you’re a woman, and know that this, too, shall pass…
Androgens (DHEA and others) – When levels of these are too high they enhance your sex drive and aggressive tendencies, produce unwanted facial hair and apple vs. pear-shaped bodies in women, stimulate your appetite and contribute to waistline weight gain.
Cortisol – This affects your metabolism and tells your body to store more (more! more!) body fat, and is produced in even higher amounts under stress. (Remember, a woman with PMDD is more sensitive to stress to start with, so don’t be surprised if your levels are off the charts.)
Think about this: Our bodies have not changed much biologically since prehistoric times, and so are designed to respond to stress in a certain way that back then was perfectly normal and balanced. But stress back then might be due to a natural disaster, imminent death or starvation, attack by a wild animal, or, in later times, attack from a warring tribe.
Now our stress comes from sources like electronic devices, over-commitment, dashed hopes and unmet expectations, financial strain, unsafe drivers, emotional upsets, and major life changes like birth, death, marriage, divorce, surgery, change in employment or living location, to name just a few.
But our bodies still react in the same way they did in prehistoric times to these threats and upsets—as if we were literally under physical attack.
So up goes your cortisol, which, among other things, suppresses your normal immune functions, leaving you susceptible to every cold and flu that comes your way. In time your body can get so run down that you develop something serious, even terminal.
The Estrogens – Estradiol, Estrone, and Estriol These three wonder hormones are involved in over 400 crucial functions throughout your body and brain, including your metabolism, moods, body heat regulation, insulin sensitivity, pain levels (think muscle and joint pain, and headaches), and carbohydrate tolerance. Both too much and too little estrogen are bad for you, in ways too numerous to go into here. But know this—you have estrogen receptors in your brain, bladder, bones, muscles, blood vessels, skin, breasts, uterus, eyes, heart, and colon. It’s not just about sex anymore. With all those receptors, you can easily take in too much estrogen—or, more appropriately, too much of the WRONG kind of estrogen (aka xenoestrogens).
Insulin – Lowers your blood sugar, stimulates fat storage.
Melatonin – Regulates your sleep cycles and body rhythms, promotes fat storage for hibernation (remember those cave dwellers) and increases your appetite for carbs. Melatonin also plays a role in Seasonal Affective Disorder (SAD) syndromes that affect your energy levels, weight gain, daytime sleepiness, and depressed moods.
Norepinephrine and Epinephrine – aka your Adrenaline Hormones. These govern your “fight or flight” responses. They increase your heart rate, lift your mood (or in excess cause anxiety), increase alertness, and dilate your arteries to provide more oxygen, glucose, and nutrients to your key organs in times of distress.
Remember what I said about how our bodies were initially designed to respond to threats and the differences between threats then and threats now? Some of us are living in a nearly constant state of fight or flight simply due to the lifestyles we live. But on top of that, when a woman enters her PMDD zone, her fight or flight switch comes on, but because of some missed connection in the brain—it does not shut off.
Until her period comes. That
can last up to three weeks in the worst cases.
Being trapped in that fight or flight state is exhausting, to
say the least. You know how you feel when you're exhausted...apply that to a
woman with PMDD ten-fold and you may begin to understand her emotional
instability during her episodes.
Progesterone –
The jury is still out on this one. Some sources say too much progesterone can increase your appetite, increase
fat storage, reduce insulin sensitivity, make you sleepy, depressed, and
depress your sex drive. Fatigue, breast
tenderness, bloating, and vaginal dryness are also symptoms. Other sources say too little progesterone can cause many of these same symptoms—in
addition to anxiety attacks, insomnia, dizziness, irritability, difficulty
concentrating, extreme changes in mood, muscle pain, joint pain, and urinary
incontinence.
Who to believe? All I
know is progesterone supplementation is something that needs to be fine-tuned
over the course of your cycle . I have found that, much like an upside-down
U-curve, there seems—for me—to be a sort of sweet spot at the top of the curve;
too little progesterone creates symptoms, too much progesterone creates
symptoms. The dosage needed can vary
daily. I have to constantly adjust and
readjust my progesterone intake, using supplementation and nutrition.
So be wary of progesterone creams, especially over-the-counter
brands. Depending on what else is in
them, you can get too much, too little, or none at all. They are not regulated. Other ingredients in the creams can also clog
your pores and provide added fake estrogens if you do not read the label carefully. Only a precious few progesterone creams perform
the way they are intended to. I use a cream
when symptoms are particularly bad, but for the most part I take a 100 mg
capsule of micronized progesterone daily, and double that on symptomatic
days. If you would like to know which
brands I use, contact me directly. (info (at) livingwithpmdd (dot) com.)
Testosterone – It’s not just for guys. Too little testosterone can negatively affect your bone and muscle growth, metabolism, mood, energy level, and sex drive.
Thymosin – This little-known hormone plays a major role in the development of your immune system. Be good to it or be betrayed by it.
Thyroid – Affects your metabolism, nervous system, muscles and bones, energy levels, heart rate, body heat production, and brain activity. (Hello? Brain activity? Remember this.)
Okay, now I’m no doctor, but if you take the major symptoms of PMDD and bump them up against these hormones, you’ll find that too much or too little of eight of them can lead to weight gain, five of them can cause problems with your metabolism, five of them can affect mood disorders, six can cause problems with your energy levels, two can make you anxious, two can make you aggressive, three affect your sex drive, two reduce insulin sensitivity, two affect sleep cycles, two can depress your immune system, and two can affect your brain function…which can affect all of the above.
Let’s break that down into something more understandable.
Imbalances (for lack of a better word) in the following can cause weight gain:
Androgens
Cortisol
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Aldosterone (water weight gain)
Imbalances in the following can cause metabolism problems:
Cortisol
Estrogen
Testosterone
Thyroid
Imbalances in the following can cause mood disturbances:
Estrogen
Progesterone
Melatonin
Testosterone
Thyroid
Imbalances in the following can cause your energy levels to plummet:
Estrogen
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Imbalances in the following can compromise your immune system:
Cortisol
Thymosin
Imbalances in the following can reduce insulin sensitivity:
Estrogen
Progesterone
Imbalances in the following can cause problems with brain function:
Estrogen
Thyroid
Or, to cross-match it another way…
DSM-V Symptoms of PMDD affected by hormone levels:
Markedly Depressed Mood (feelings of hopelessness, or self-deprecating thoughts)
Estrogen
Progesterone
Melatonin
Testosterone
Thyroid
Marked Anxiety, Tension, Feeling Keyed-up or On Edge
DHEA
Norepinephrine
Epinephrine
Thyroid
Marked Affective Lability (feeling suddenly sad or tearful or increased sensitivity to rejection)
Estrogen
Progesterone
Persistent and Marked Anger, Irritability, or Increased Interpersonal Conflicts
DHEA and other Androgens
Testosterone
Thyroid
Decreased Interest in Usual Activities (work, school, friends, hobbies)
Estrogen
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Subjective Sense of Difficulty in Concentrating
Estrogen
Progesterone
Thyroid
Decreased Interest in Usual Activities (work, school, friends, hobbies)
Estrogen
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Subjective Sense of Difficulty in Concentrating
Estrogen
Progesterone
Testosterone
Thyroid
Lethargy, Easy Fatigability, Marked Lack of Energy
Estrogen
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Marked Change in Appetite, Overeating, or Specific Food Cravings
DHEA
Cortisol
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Hypersomnia or Insomnia
Estrogen
Melatonin
Thyroid
Subjective Sense of Feeling Overwhelmed or Out of Control
Estrogen
Progesterone
Thyroid
Lethargy, Easy Fatigability, Marked Lack of Energy
Estrogen
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Marked Change in Appetite, Overeating, or Specific Food Cravings
DHEA
Cortisol
Insulin
Melatonin
Progesterone
Testosterone
Thyroid
Hypersomnia or Insomnia
Estrogen
Melatonin
Thyroid
Subjective Sense of Feeling Overwhelmed or Out of Control
Estrogen
Progesterone
Thyroid
Physical Symptoms, such as breast tenderness or swelling, headaches, joint or muscle pain, a sensation of bloating, or weight gain.
Aldosterone (water weight gain)
Estrogen
Progesterone
Cortisol
Insulin
Melatonin
Testosterone
Thyroid
Do you see where I’m going with this? You could have PMDD, or you could have some kind of hormonal excess or deficiency that is exacerbated pre-menstrually (called Pre-Menstrual Exacerbation). It might actually be an insulin problem, or a thyroid problem, an auto-immune system problem, and not PMDD at all. Some doctors have been making great strides with theories of inflammation. Your problem might be PMDD or it might be something entirely different.
Physical Symptoms, such as breast tenderness or swelling, headaches, joint or muscle pain, a sensation of bloating, or weight gain.
Aldosterone (water weight gain)
Estrogen
Progesterone
Cortisol
Insulin
Melatonin
Testosterone
Thyroid
Do you see where I’m going with this? You could have PMDD, or you could have some kind of hormonal excess or deficiency that is exacerbated pre-menstrually (called Pre-Menstrual Exacerbation). It might actually be an insulin problem, or a thyroid problem, an auto-immune system problem, and not PMDD at all. Some doctors have been making great strides with theories of inflammation. Your problem might be PMDD or it might be something entirely different.
The reason to get a diagnosis of PMDD is not to brand you with
the PMDD label, but rather to rule out any other treatable causes for your
symptoms.
Once you get that something else identified and dealt with, you
might be left with only PMS to deal with.
And wouldn't that be wonderful?
The bottom line is only you and a caring, knowledgeable, and
forward-thinking medical professional will be able to identify and separate the
many connected hormonal threads in your body and figure out what's working
right and what is not.
You are a beautiful, complex system of individual ups and downs, highs and
lows, checks and balances. Don’t let medical
professionals simply hand you prescriptions for one-size-fits-all blanket treatments
and/or try to make you feel to blame or as if you are not trying hard enough when
they don't work.
And most of all, don't let anybody tell you you’re crazy.
Because the only things out of kilter here are your hormones.
Keep searching until you find the right practitioner and answers
for YOU.
Labels:
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